Hemoglobin Videos

(November 12, 2009 - Insidermedicine) From Pittsburgh - High hemoglobin levels may be a predictor of diabetic retinopathy later in life, according to a report published in the Archives of Ophthalmology. Researchers followed 426 diabetic patients for 18 years. For ever 1 g/dl increase in hemoglobin levels, men were at 29% increased risk of diabetic retinopathy, while women saw their risk increase by 10%. From Mexico - While young people are more likely to get the H1N1 flu, older people are more likely to die from it, according to a report published in The Lancet. Researchers found several interesting statistics on over 63, 000 cases of flu-like illnesses studied: 10.3% of those aged 70 and older who were infected died, while only 0.9% of those aged 20-29 died; 6% of pregnant women with H1N1 died; nearly 1% of all H1N1 cases died; the risk of catching H1N1 fell by 35% for those vaccinated for the seasonal flu; chronic underlying illnesses raised risk 6 fold; and finally, people who did not go to the hospital within four days of developing H1N1 symptoms had a 20% increased risk of death for each day they put off going to the hospital. And finally, from St. Louis - According to a report published in the journal Science Translational Medicine, a Westernized diet may lead to obesity through microbes found in the gut. Researchers implanted human intestinal microbes into mice and changed the rodents food from a plant based, low fat diet to a diet high in both fats and sugars. Results showed that microbes linked with obesity were immediately found in the mice intestines after the change in diet, with the mice eventually becoming obese.

Professor George Wolfe discusses hemoglobin as a buffer in this video from Thinkwell's online Biology series.

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Folic acid isn't just for pregnant women! Find out why absolutely everyone needs this vital vitamin.

Author: fullturn Added: Wed, 19 Mar 2008 01:37:35 -0800 Duration: 76Folic acid isn't just for pregnant women! Find out why absolutely everyone needs this vital vitamin.

#0031 Report from NIH Research Radio -- Topics for Friday, May 4, 2007 Coming up on this edition, a clinical trial from the National Heart, Lung and Blood Institute shows that people with pre-hypertension who reduced their sodium intake by 25 to 35 percent had a 25 percent lower risk of total cardiovascular disease over the 10 to 15 years during which they cut back on salt. Special Correspondent Belle Waring tells us about a clinical research trial she's volunteered for. The National Eye Institute marks Healthy Vision Month with some information on how to get yourself checked for glaucoma. There are some new insights into how cells repair their DNA that could point the direction to a possible way to stop or slow the onset of Huntington's disease. And we hear about the importance of HIV Vaccine Awareness Day, which is coming up on May 18. But first, Wally Akinso shares a report that shows how having elevated risk factors as a young adult increases the likelihood of coronary calcium deposits later in life. Episode #0031 show notes E-mail Bill Schmalfeldt Podcast archives

The genes for the protein chains of hemoglobin show small differences within different human populations, so the amino acid sequence of hemoglobin is slightly different from person to person. In most cases the changes do not affect protein function and are often not even noticed. However, in some cases these different amino acids lead to major structural changes. One such example is that of the sickle cell hemoglobin, where glutamate 6 in the beta chain is mutated to valine. This change allows the deoxygenated form of the hemoglobin to stick to each other, as seen in PDB entry 2hbs, producing stiff fibers of hemoglobin inside red blood cells. This in turn deforms the red blood cell, which is normally a smooth disk shape, into a C or sickle shape. The distorted cells are fragile and often rupture, leading to loss of hemoglobin. This may seem like a uniformly terrible thing, but in one circumstance, it is actually an advantage. The parasites that cause the tropical disease malaria, which spend part of their life cycle inside red blood cells, cannot live in the fiber-filled sickle cells. Thus people with sickle cell hemoglobin are somewhat resistant to malaria. Other circumstances leading to troubled hemoglobins arise from a mismatch in the production of the alpha and beta proteins. The structure requires equal production of both proteins. If one of these proteins is missing, it leads to conditions called Thalassemia. You can look at the binding of oxygen up close in two structures of human hemoglobin. PDB entry 2hhb shows hemoglobin with no oxygen bound. In this picture, the heme is seen edge-on with the iron atom colored in gold. You can see the key histidine reaching up on the bottom side to bind to the iron atom. In PDB entry 1hho, oxygen has bound to the iron, pulling it upwards. This in turn, pulls on the histidine below, which then shifts the location of the entire protein chain. These changes are transmitted throughout the protein, ultimately causing the big shift in shape that changes the binding strength of the neighboring sites.

In this activity, experts in hematology and oncology discuss current challenges in the early recognition and optimal management strategies for anemia of cancer.

In this activity, experts in the treatment of perioperative anemia present the most current data on efficacy and safety of erythropoietic strategies to minimize transfusion and improve outcomes. Other blood conservation strategies, as well as data in specific oncologic settings and within the ICU, will be addressed.

In this activity, experts in oncology present the most current data on antiangiogenic therapy for advanced colorectal cancer. Standard therapeutic approaches for metastatic CRC are discussed, latest findings from clinical trials evaluating efficacy and safety of antiangiogenic therapy in advanced CRC are summarized, and clinical implications of these findings are assessed. Based on data presented at ASCO-GI 2006. This content is not a publication of, sanctioned by, or an official part of the American Society of Clinical Oncology Gastrointestinal Cancers Symposium 2006. The materials presented here are used with the permission of the authors and/or other sources. These materials do not necessarily reflect the views of PeerView Press or any of its supporters.