A man who has been nicknamed Dr Death is to hold his first do-it-yourself suicide workshop in the UK. Dr Philip Nitschke, an Australian who wants to help people die in countries where euthanasia or assisted suicide is not allowed, and Sarah Wootton, of the campaign body to allow assisted suicide Dignity In Dying, discuss whether Dr Nitschke's actions have the potential to harm vulnerable people.

The FTSE index of leading UK shares has fallen over 400 points on opening. In the US, the Dow Jones has fallen to its lowest level in five years. Reporter Nick Cosgrove and Gillian Tett, of the FT, give the latest developments.

The City has had a day to digest the UK government's plans for the banks, and the FTSE 100 fell over 5%. Jim O'Neill, of Goldman Sachs, and Neil Mackinnon, of ECU Group, discuss whether this is an omen for the economy.

The mayor of London Boris Johnson claims that the rate of violent crime, in particular knife crime, is falling. This follows the resignation of Sir Ian Blair, former head of the Met. The Conservative mayor came under a lot of criticism for his role in Sir Ian's departure. Mr Johnson discusses the "decision to turn the switch off" the Met chief's tenure.

Presidential candidates John McCain and Barack Obama have clashed in their second televised debate. North America editor Justin Webb reports on who got the upper hand.

The British government has disclosed a rescue package for the country's finance industry. Chancellor Alistair Darling says the banking system has not been working, but this package will help banks to restructure.

What are the effects of the turmoil on financial markets on the "real economy" and small businesses? Stephen Alambritis, of the Federation of Small Businesses and Timothy Melgund, chief executive of stationers Paperchase, discuss whether the UK economy is "already in a recession".

Human evolution is over, according to a leading geneticist. Professor Steve Jones, of University College London, says the human race is as fit strong, intelligent and healthy as it ever is going to be.

Developing countries, including China, should not have to commit to any emissions reductions until 2020, a review suggests. Author of the Stern Review, Lord Nicholas Stern, discusses "a global deal for climate change".

Banks the world over are failing, with German rescues following the US bail-out. Robert Peston says there is a UK contingency plan, but Treasury Secretary Yvette Cooper says it would be "irresponsible to speculate".

The bail-out package which has now been agreed by US Congress is designed to put a firewall around the "toxic assets" which are seen as at the root of the financial crisis. But at the end of the day's trading, Wall Street ended significantly down. Business editor Robert Peston and George Magnus, senior adviser to UBS Investment Bank, discuss whether the crisis really can be solved with the existing rescue plan.

In Gordon Brown's cabinet reshuffle, Peter Mandelson's return still dominates political debate. Ed Miliband, new secretary of state for energy and climate change, discusses his own move to the "front rank of politics".

Met Police Commissioner Sir Ian Blair has resigned, amid a row about whether he was forced to go by London mayor Boris Johnson for political reasons. Former Home Secretary David Blunkett, and Ken Jones, president of the Association of Chief Police Officers, discuss whether politics should influence policing.

A European financial summit to discuss the current global crisis is set to take place in Paris, with rumours that an EU-wide bail-out could be proposed. Europe correspondent Jonny Dymond reports on European governments' opinion of the idea of a joint action plan and Sir Howard Davies, former chairman of the FSA, says the notion of a common fund for bail-outs is a non starter.

John McCain's Republican Party running mate Sarah Palin is to face Democrat running mate Joe Biden in the US vice-presidential debate. North America editor Justin Webb reports on the toughest test yet for the hockey mom politician.

The UK economy is facing a difficult future whether or not the bail-out bill is passed in the US. Marks and Spencer boss Sir Stuart Rose and Richard Lambert, director general of the CBI, debate the growing economic gloom.

The Royal Society is to announce it will invest £1m annually in 'blue skies' scientific discovery. The Theo Murphy Blue Skies Award will support research in the fields of science, technology and engineering. Professor Christofer Toumazou, of Imperial College London, will chair the panel for the award. He says that it should lead to some useful new discoveries.

Despite concerns expressed in the papers about the Lloyds TSB takeover of HBOS, Sir Brian Pitman is confident it will go ahead. The former chairman of Lloyds TSB also says the current crisis is "clearing out the stables" and the UK will be left with five or six large, safe institutions.

It is 70 years since the Munich agreement, allowing Hitler to annex part of what was then Czechoslovakia, was signed. Historians David Faber and Dr David Dutton discuss whether the generally-unfavourable reputation of then Prime Minister Neville Chamberlain was justified.

Shares across the world have slumped following the rejection of a $700bn (£380bn) Wall Street bail-out plan. Economist Steven Bell, of GLC Hedge Funds, says the financial system is broken and the credit process is blocked. Conservative leader David Cameron discusses what can be done to ease the economic situation in the UK.

Senators and members of the House of Representatives in Washington are to vote on the new $700bn deal to rescue America's financial system and end the credit crunch. Mark Bloomfield, president of the tax-cutting lobby group American Council for Capital Formation, discusses the consequences of the legislation on the re-election of members of Congress.

The life of Bradford & Bingley as a bank is coming to an end. Fortis bank, a giant of Belgium and Holland, is also being rescued. And in the US, an amended version of the bail-out plan is agreed. Chancellor Alistair Darling discusses further turmoil in the financial sector and Shadow Chancellor George Osborne says that the City must bear part of the cost and blame for the current financial crisis.

With the race still hanging on a knife edge, this round of presidential debates may have a decisive effect on who becomes the next US president. Kevin Connolly gives his analysis of the performances of John McCain and Barack Obama.

The government has unveiled the pictures - of rotting teeth, corpses being cut open and giant abscesses - that will be printed on packs of cigarettes from next week. Simon Clarke, of the smokers' organisation Forest, and Bryan Stoten, chairman of the NHS Confederation discuss whether the move is a good idea.

Half of Europe's frogs and toads and newts could be wiped out in the next 40 years, the Zoological Society of London suggests. Sir David Attenborough, a fellow of the society, explains why he thinks this is likely to happen.

Talks in Washington have so far failed to reach agreement on a massive $700bn (£380bn) government proposal to bail out the troubled US finance sector. Vincent Reinhart, former director of monetary affairs at the Federal Reserve, says that Paulson's plan was flawed from the outset.

President Bush has warned of dire consequences for the US economy if Congress rejects a rescue package for Wall Street. US Congressman John Spratt discusses the chances of a deal being agreed.

The media regulator Ofcom will publish the second stage of its report into Public Service Broadcasting (PSB). It is expected to suggest that rules that cover regional news bulletins on ITV should be relaxed. Ofcom's chief executive Ed Richards discusses whether ITV will have its PSB remit reduced.

Eleven members of the South African cabinet, including finance minister Trevor Manuel, say they are resigning along with President Thabo Mbeki. The country's financial markets have not reacted well. Hendrik du Toit, of Investec Asset Management, and Peter Bruce, of South Africa's Business Day newspaper, discuss the financial implications of the political unrest.

The Prime Minister's highly personal speech has been seen as a success by the Labour ranks. Gordon Brown discusses whether the good mood will last and if the idea of "a fair society" will win Labour a fourth term.